The geopolitical dynamics in Southeast Asia after the Covid-19 pandemic have experienced significant changes that affect relations between countries, regional security and the economy. The pandemic has not only highlighted the vulnerabilities of health systems, but has also accelerated shifts in political and economic power in the region. One of the most striking impacts is increased competition between the United States and China. These two countries are trying to expand their influence in Southeast Asia, with different strategies. While the US prioritizes security cooperation and economic assistance, China offers investment through infrastructure projects, such as the Belt and Road Initiative (BRI). Countries in Southeast Asia, such as Indonesia, Malaysia, and Vietnam, face the dilemma of choosing between these two great powers, often trying to balance relations to ensure their national interests remain secure. In the security context, the South China Sea issue remains the main focus. Overlapping territorial claims between China and several ASEAN member countries, such as the Philippines and Vietnam, create tensions. Increased military activity and naval exercises in the region show that these tensions have not eased post-pandemic. ASEAN countries recognize the need for solidarity in facing this challenge, and initiatives such as a code of conduct in the South China Sea have become an important topic of discussion in regional forums. Southeast Asian economies are also undergoing transformation. The pandemic is driving accelerated digitalization, increasing the use of information technology in trade. E-commerce and fintech are fast-growing sectors, creating new opportunities especially for small and medium businesses. Apart from that, supply chain diversification has also emerged as a major need. Countries in the region are trying to reduce dependence on any one country, given the potential disruption caused by the global health crisis. In responding to these challenges, the role of regional organizations such as ASEAN is very important. Continued cooperation between countries is needed to face common issues, whether related to health, economy or security. However, internal challenges within ASEAN, such as differences in political and economic interests between members, remain and require careful mediation. The health crisis also opens up new spaces for cooperation in the health sector. Countries in Southeast Asia are starting to form alliances to strengthen public health systems, share vaccines and medical technology. This step shows awareness of the importance of collaboration in dealing with future pandemics. Finally, the socio-political dynamics in this region have not gone unnoticed. The pro-democracy movement and demands for human rights in several countries, such as Myanmar, show that people’s aspirations for change cannot be ignored. This could trigger instability and have implications for regional politics. Overall, geopolitical changes in post-pandemic Southeast Asia are creating a complex new landscape. Each country must be careful in formulating foreign policy, balancing national interests and regional cooperation, to ensure long-term security and stability. Efforts to face global challenges and increase social, economic and political resilience are the main priorities in building a better future for this region.